151751-Najiba-Chargi

67 Diagnostics: measuring skeletal muscle mass of the musculus masseter Table 7. (Continued) Risk factor HR 95% CI p-value L3 CSA 0.99 0.98 – 1.0 0.03 C3 CSA 0.95 0.91 – 1.0 0.04 Body mass index (kg/m 2 ) <20 (underweight) Ref. 20-24.9 (normal weight) 1.61 0.84 – 3.10 0.29 25-29.9 (overweight) 0.52 0.26 – 1.03 0.06 ≥30 (obese) 1.40 0.61 – 3.22 0.43 Body mass index 0.95 0.90 – 1.01 0.13 Body surface area 0.71 0.52 – 0.96 0.02 Charlson comorbidity index 1.28 1.15 – 1.44 <0.001 Teeth (categorized) No teeth missing ref One or more dental elements missing 1.07 0.52 – 2.22 0.85 Complete lack of denture 0.12 0.64 – 2.41 0.52 Smoking status (never vs. ever) 1.41 0.61 – 3.29 0.42 Alcohol status (never vs. ever) 1.01 0.50 – 2.06 0.97 Localization (oropharynx vs. other) 0.70 0.41 – 1.18 0.18 Stage (I-II vs. III-IV) 1.17 0.62 – 2.21 0.62 T-stage (T1-T2 vs. T3-T4) 1.08 0.65 – 1.80 0.76 Treatment (CRT vs. other) 0.63 0.35 – 1.15 0.13 Surgery (yes vs. no) 1.21 0.70 – 2.10 0.44 Table 8. Multivariable Cox regression analysis Risk factor HR 95% CI p-value Charlson comorbidity index 1.34 1.16 – 1.53 <0.001 Low MSMI 3.03 1.52 – 6.03 0.002 L3 CSA 1.00 0.98 – 1.02 0.99 C3 CSA 1.00 0.95 – 1.06 0.93 OVERALL SURVIVAL Mean overall survival for patients with low MSMI was 16.81 months (IQR 10.92 – 54.86) com - pared to 32.82 months (IQR 12.21 – 59.55) for patients with normal MSI (log rank p = 0.07; Figure 3). There was no significant difference in overall survival between patients with low and normal LSMI using the previously established cut-off value of LSMI ≤43.2 cm 2 /m 2 (Figure 4). 11 4