Yoeri Bemelmans

Chapter 2 28 Ethical approval statement This studywas performed in compliancewith theHelsinki Declaration of 1975, as revised in 2013 and was studied and approved by the IRB and conducted in accordance with the guidelines for Good Clinical Practice. IRB-approval was obtained from the Regional Ethics Committee of Heerlen (METC Z, Heerlen, the Netherlands, IRB Nr. METCZ 17- N-53). All patients who participated in the study gave their written informed consent. Funding This researchdidnot receive any grants fromfunding agencies in the public, commercial, or non-for-profit sectors. Declaration of competing interest All authors declare that they have no conflict of interest to report. Acknowledgements The authors are thankful for the effort of Caroline Niebuhr and Lisa Schröder for their work in collection of the data.