Yoeri Bemelmans

Chapter 3 34 either operated in the inpatient pathway, with an average length of hospital stay of 2 days, or as anoutpatientwithdischarge fromthehospital on thedayof surgery [18]. Blood typing and crossmatching was performed preoperatively in all patients. Patients were screened for preoperative anaemia and if deemednecessary, further analysedpreoperatively inour hospital. Operations were performed under general or spinal anesthesia (with or without sedation). All patients received antibiotic prophylaxis (intravenous (IV) administration of 2000mg (<100 kg); 3000mg (>100 kg) Cefazolin) in three doses; 15-60min before incision, 8 and 24hrs postoperative. In case of a known allergy for Cefazolin, Vancomycin (IV administration of 1000mg (<100 kg); 1500mg (>100 kg), preoperative dose and 12hrs postoperative second dose) was given. For patients following the outpatient pathway, the last dose was not given due to practical consideration. Figure 1. Patient selection process. Arthroplasty related surgeries, n= 6394 Excluded patients, n= 1189  Trauma related, n= 627 (e.g. hemi- hip arthroplasty, periprosthetic fractures)  Revision surgery, n= 328 (e.g. stem/cup revision, bearing change)  Complication related, n= 234 (e.g. persistent wound leakage, infection, luxation, arthrofibrosis, puncture) Included, n= 5205  UKA, n= 412  TKA, n= 2546  THA, n= 2247 Patients received blood transfusion within the total cohort * , n= 49  TKA, n=16  THA, n=33 TXA was given in two doses. First dose was given orally (Cyclokapron ® , Mylan, Hatfield, United Kingdom) 2hrs before incision by the nurse on the orthopaedic ward. Second dose was given IV (Cyclokapron ® , Pfizer, New York City, United States) at the end of the surgery when the wound was closed, administered by the anaesthesiology assistant.