Yoeri Bemelmans

Tranexamic acid in hip and knee arthroplasty 41 3 embolic events were found after the implementation of high-dose TXA in other studies [8,9,19,28]. In advantage of these results, the current protocol consists of a low-dose TXA protocol and should therefore be safe to implement in daily practice. Another possible limitation of the study is the lack of correction for anti-coagulant usage. This could potentially bias the blood transfusion rates due to the negative influence on perioperative blood loss. Conclusions Substantiated among with high-quality trials, TXA use in primary hip and knee arthroplasty holds an indispensable role in the perioperative process. As presented in this retrospective cohort study, an oral and IV administration protocol of TXAwas found to be effective and safe for primary hip and knee arthroplasty procedures. Acknowledgements The authors are thankful for the effort of Claudy van Thoor for her work in collection of all the data.