Harmen Beurmanjer

55 Cognitive Impairments in Patients with GUD 4 were common, with 41.4% reporting five or less GHB comas, 18.4% between six and nineteen times, 19.5% between twenty and fifty times, and 20.7% reported to have experienced more than fifty comas in their lifetime. Co-morbid substance use in the past 30 days was the highest for nicotine (83,7%), followed by stimulants (50%), alcohol (43,5%), cannabis (33,7%) and cocaine (33,7%). Scores on MoCA Patients scored on average 24.2 points on the MoCA (SD: 3.01) at T1 and 25.8 points (SD: 2.78) at T2, with a trend towards significance (Wilks’ Lambda=.903, F(1,38)=4.076, p=.051) for patients with both a MoCA on T1 and T2, see Table 1 . Fewer patients scored below the cut-off score on T2 than on T1 (χ 2 (1) = 5.214 p= .022). In total 27 patients improved their scores between T1 and T2, five had the same score and seven had a lower score. On domain level, patients performed lowest on Memory and highest on Orientation on both T1 and T2. No significant differences were observed on domain level between T1 and T2. Relationship between GHB coma, GHB use, and cognitive impairment MoCA total scores did not correlate with number of comas, GHB dose, total length of GHB use, length of daily GHB use and GHB exposure score on both T1 and T2, see supplement II. Relationship between relapse and cognitive impairment Patients who remained abstinent at follow-up scored higher on Attention, Memory and Total score at T1 in comparison with patients who relapsed in GHB use between detoxification and follow up. More patients who remained abstinent scored above the cut Table 1 MoCA-scores on T1 and T2 T1 (n=39) T2 (n=39) Mean (sd) % Mean (sd) % Executive Functioning & Visuospatial Abilities (0-6) 4.36 (1.20) 72.7% 4.74 (1.17) 79.0% Attention (0-6) 5.00 (1.07) 83.3% 5.13 (1.08) 85.5% Language (0-5) 4.40 (1.05) 88.0% 4.66 (0.63) 92.2% Abstract Reasoning (0-2) 1.63 (0.62) 81.5% 1.81 (0.44) 90.5% Memory (0-5) 2.94 (1.58) 58.8% 3.52 (1.54) 70.4% Orientation (0-6) 5.84 (0.48) 97.3% 5.79 (0.48) 96.5% Total (0-30) 24.16 (3.01) 80.1% 25.65 (2.78) 85.5% Below cut-off* 56.3% 30.6% *p<.005 % comprises the mean percentage of points obtained on the Montreal Cognitive Assessment.