Harmen Beurmanjer

83 Baclofen for GHB-Dependent Patients 6 Side effects Patients reported overall limited side effects, with the most frequently reported being: feeling tired (28%), sleepiness (14%) and feeling depressed (14%). No serious adverse events were reported. Table 1 Demographics and GHB use per sub group. Treatment as usual (N=70) Baclofen + Treatment as usual (N=37) Test statistic p Male % 54% 74% χ²=4.68 .030 Age. mean (SD) 28.9 (7.8) 29.5 (7.0) F(1.98)=.014 .905 Employment % 31% 32% χ²=0.01 .916 GHB use. mean (SD) - Months using GHB 58.3 (42.2) 63.5 (43.0) F(1.85)=.285 .595 - Months using daily GHB 27.4 (28.2) 41.2 (43.0) F(1.79)=2.958 .089 - GHB gram daily 55.6 (53.8) 46.1 (40.9) F(1.93)=0.797 .374 - Interval between doses (hours) 1.8 (0.73) 1.84 (0.64) F(1.85)=0.114 .736 Table 2a Comparison of (re)lapse in GHB use in the three months after detoxification between patients prescribed baclofen (ITT) and patients who received treatment as usual. Treatment as usual Baclofen + Treatment as usual Test statistic p-value Patient completed follow-up Lapse (any use) N=55 47% (n=26) N=35 46% (n=16) χ²=0.20 .885 Relapse Patients including drop-out 38% (n=21) N=70 20% (n=7) N=37 χ²=3.29 .069 Relapse† 50% (n=35) 24% (n=9) χ²=6.59 .010 † Drop-out is considered relapse in GHB dependent patients, therefore only relapse is mentioned.