Joost Peerbooms

120 Chapter 7 Appendix Table A1 For all outcome measures the results of Little’s MCAR test Outcome measure Chi-Square test P -value FFI Pain χ 2 (30) = 16.330 0.980 FFI Disability χ 2 (27) = 21.993 0.738 FFI Activity χ 2 (27) = 24.285 0.614 AOFAS χ 2 (28) = 17.190 0.945 WHOQOL Overall QoL and General Health χ 2 (24) = 19.058 0.749 WHOQOL Physical Health χ 2 (27) = 25.478 0.548 WHOQOL Psychological Health χ 2 (27) = 32.715 0.207 WHOQOL Social Relationships χ 2 (24) = 47.296 0.265 WHOQOL Environment χ 2 (27) = 27.631 0.430 Abbreviations: QoL = Quality of Life, FFI = Foot Function Index, AOFAS = American Orthopaedic Function & Ankle Society; WHOQOL = World Health Organization Quality of Life instrument Appendix Table A2 For all outcome measures the results of the F -test on the three-way interaction between treatment, dosage and time, both for models with- and without adjustment for quadratic and cubic time effects Outcome measure Time modelled linearly Time modelled linearly, quadratically and cubically F -test P -value F -test P -value FFI Pain† F(1,96.636) = 3.157 0.079 F(1,178.136) = 0.237 0.627 FFI Disability† F(1,117.726) = 0.434 0.511 F(1,210.527) = 0.602 0.439 FFI Activity† F(1,122.073) = 0.001 0.977 F(1,203.000) = 0.235 0.628 AOFAS† F(1,126.834) = 1.919 0.168 F(1,212.003) = 1.249 0.265 WHOQOL Overall QOL and General Health F(1,116.196) = 2.687 0.104 F(1,213.489) = 0.475 0.491 Physical Health† F(1,122.828) = 3.645 0.059 F(1,175.282) = 1.549 0.215 Psychological Health F(1,113.226) = 0.747 0.389 F(1,167.989) = 1.320 0.252 Social Relationships F(1,104.084) = 3.447 0.066 F(1,187.336) = 0.085 0.771 Environment F(1,126.952) = 0.631 0.429 F(1,192.948) = 2.174 0.142 * Statistically significant based on the criteria reported in our statistical analysis paragraph † These models showed significant quadratic- and cubic time effects Primary outcome measure