15250-m-cuypers

52 Chapter 3 3. RESULTS Three hundred and eighty eight patients gave informed consent of which 377 patients completed the first completed the first questionnaire (t0, response rate 97.2%). All patients whose biopsy confirmed Pca (n=126 patients, 32%), received the follow-up questionnaire (t1, response rate 63%) (Figure 1). There were no statistically significant differences in demographics between patients with cancer and patients without cancer at t0, between responders at t0 and t1, or between responders and non-responders at t1. Patient demographics are presented in Table 1. 3.1 Health-related quality of life At the pre-biopsy baseline (t0), HRQoL did not differ between patients whose biopsy result confirmed Pca, and patients with a negative biopsy result (Table 2). After receiving diagnosis and treatment decision-making (t1), patients reported worse role and cognitive functioning and more symptoms (fatigue, constipation, urinary, bowel, and hormonal). Sexual activity and functioning improved after treatment was chosen (all with p <0.05, Table 2). 388 patients scheduled for prostate biopsy consented to participate 377 Patients filled out first questionnaire (97.2%) 11 Patients did not return first questionnaire (2.8%) 254 patients with negative biopsy result 123 patients diagnosed with Pca 3 patients diagnosed with Pca 8 patients with negative biopsy result 126 patients received follow-up questionnaire after diagnosis 80 patients filled out follow-up questionnaire (63.5%) 46 patients did not return follow-up questionnaire (36.5%) Figure 1. Patient flow