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54 Chapter 3 Table 2. HRQoL scores HRQoL core No Pca Pca Mean difference (t1-t0)1 t0 (N=254) Mean (SD) t0 (N=123) Mean (SD) t1 (N=80) Mean (SD) Global Health 83.5 (14.8) 83.7 (15.4) 80.7 (16.1) -3.0 Physical functioning 94.2 (10.4) 94.3 (10.1) 92.8 (12.7) -1.5 Role functioning 94.7 (14.9) 96.0 (12.9) 86.1 (24.2) -9.9 *** Emotional functioning 85.3 (16.0) 85.0 (16.8) 83.4 (19.9) -1.6 Cognitive functioning 91.2 (15.0) 92.3 (12.5) 88.9 (16.9) -3.4 * Social functioning 95.0 (13.9) 96.2 (10.1) 93.9 (14.3) -2.3 Fatigue 11.4 (17.3) 10.7 (15.5) 17.0 (22.3) 6.3 ** Nausea/vomiting 1.0 (4.7) 1.1 (5.2) 2.4 (11.9) 1.3 Pain 6.8 (15.8) 5.8 (12.6) 9.4 (19.8) 3.6 Dyspnoea 7.7 (16.9) 6.5 (15.3) 6.8 (17.3) 0.3 Insomnia 14.4 (23.8) 13.8 (21.5) 15.0 (25.6) 1.2 Appetite loss 1.9 (8.2) 2.0 (7.9) 4.7 (16.8) 2.7 Constipation 1.7 (8.0) 4.2 (12.7) 7.7 (20.0) 3.5 * Diarrhea 4.0 (13.4) 3.4 (11.0) 6.8 (18.9) 3.4 Financial difficulties 2.6 (12.3) 0.8 (5.3) 2.6 (12.9) 1.8 Prostate specific Urinary symptoms 15.9 (13.4) 13.3 (11.8) 17.6 (15.6) 4.3 * Bowel symptoms 3.0 (6.3) 2.7 (5.8) 5.6 (10.5) 2.9 ** Hormonal symptoms 3.5 (5.8) 3.8 (5.8) 7.0 (9.4) 3.2 *** Sexual activity 63.1 (21.6) 61.5 (22.2) 65.4 (21.3) 3.9 ** Sexual functioning 22.9 (20.3) 23.4 (19.6) 34.5 (24.0) 11.1 * All scales are 0-100; for functioning subscales, full functioning is represented by a score of 100, for symptoms, absence of symptoms is represented by score of 0. All comparisons at t0 between patients with and without cancer were non-significant 1 Paired comparison t1 vs t0 (N=70) * p <.05 ** p <.01 *** p <.001 3.2 Treatment choice In case Pca was detected, symptoms and functioning reported prior to biopsy (t0) was not associated to selection of a particular treatment. At the time point after treatment decision-making (t1),menwho chose a curative treatment reported reduced functioning and more symptoms compared to men who selected AS (Table 3). No associations were found between treatment choice and personality characteristics (data not shown).