15250-m-cuypers

55 HRQoL changes prior to Pca treatment onset 3 Table 3. HRQoL changes grouped per treatment decision HRQoL core AS N=23 Curative treatment (RP or RT) N=38 t0 Mean (SD) t1 Mean (SD) t0 Mean (SD) t1 Mean (SD) Global Health 86.4 (15.8) 87.9 (10.5) 81.4 (14.4) 75.0 (18.8) Physical functioning 93.9 (10.1) 94.2 (10.7) 93.3 (13.2) 92.3 (15.3) Role functioning 97.0 (9.8) 97.0 (9.8) 95.5 (16.0) 79.7 (29.3) ** Emotional functioning 89.8 (14.5) 92.0 (13.0) 85.1 (17.7) 77.6 (23.7) * Cognitive functioning 90.5 (13.5) 92.1 (10.2) 91.2 (12.1) 85.5 (20.9) * Social functioning 93.1 (11.0) 99.2 (3.6) * 96.8 (8.6) 90.5 (18.7) * Fatigue 10.1 (12.8) 8.6 (12.8) 10.5 (16.1) 21.6 (26.8) ** Nausea/vomiting 3.0 (8.4) 2.3 (5.9) 0 (0.0) 16.5 (2.7) Pain 5.3 (14.9) 3.0 (8.4) 7.0 (14.3) 15.4 (25.8) Dyspnoea 7.6 (14.9) 6.1 (16.7) 7.9 (19.7) 8.8 (20.0) Insomnia 9.1 (15.2) 6.1 (16.7) 16.7 (24.2) 22.8 (31.1) Appetite loss 4.5 (11.7) 1.5 (7.1) 2.6 (9.1) 8.8 (22.8) Constipation 1.5 (7.1) 1.5 (7.1) 4.4 (13.8) 13.2 (26.3) * Diarrhea 3.0 (9.8) 3.0 (9.8) 4.4 (11.4) 11.4 (24.8) Financial difficulties 0.0 (0.0) 1.5 (7.1) 0.9 (5.4) 3.5 (17.0) Prostate specific Urinary symptoms 19.3 (12.9) 14.1 (10.4) 10.3 (8.7) 19.0 (18.4) ** Bowel symptoms 2.2 (6.3) 2.2 (4.5) 3.1 (5.2) 8.6 (13.4) * Hormonal symptoms 3.9 (4.9) 5.6 (6.7) 3.0 (4.9) 6.4 (10.0) * Sexual activity 60.9 (27.3) 63.0 (18.1) 58.6 (20.3) 68.0 (20.9) * Sexual functioning 25.0 (17.9) 23.8 (19.6) 22.2 (16.4) 29.6 (18.4) All scales are 0-100; for functioning subscales, full functioning is represented by a score of 100, for symptoms, absence of symptoms is represented by score of 0. AS = Active surveillance; RP = Radical prostatectomy; RT = Radiotherapy * p <.05 ** p <.01 3.3 Psychological variables Prior to biopsy (t0), optimism was a significant predictor for global health (B=.31, p <.001). After receiving diagnosis and treatment decision-making (t1), a positive association was found between global health and decisional self-efficacy (B=.29, p =.04). Of the Big five traits, extraversion (B=.14, p =.03) , and neuroticism (B=-.17, p =.01) , were significant predictors for global health at t0, no relations were found at t1.