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59 HRQoL changes prior to Pca treatment onset 3 REFERENCES 1. Arnold M, Karim-Kos HE, Coebergh JW, Byrnes G, Antilla A, Ferlay J, et al. Recent trends in incidence of five common cancers in 26 European countries since 1988: Analysis of the European Cancer Observatory. European Journal of Cancer. 2015;51(9):1164-87. 2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2015;136(5):E359-E86. 3. Cremers RGHM, Karim-Kos HE, Houterman S, Verhoeven RHA, Schröder FH, van der Kwast TH, et al. Prostate cancer: Trends in incidence, survival and mortality in the Netherlands, 1989–2006. European Journal of Cancer. 2010;46(11):2077-87. 4. Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, et al. EAU-ESTRO- SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. European Urology. 2017;71(4):618-29. 5. Lane BR, Zippe CD, Abouassaly R, Schoenfield L, Magi-Galluzzi C, Jones JS. Saturation Technique Does Not Decrease Cancer Detection During Followup After Initial Prostate Biopsy. The Journal of Urology. 2008;179(5):1746-50. 6. SobinLH, Fleming ID.TNMclassificationofmalignant tumors, (1997). Cancer. 1997;80(9):1803- 4. 7. Pardo Y, Guedea F, Aguiló F, Fernández P, Macías V, Mariño A, et al. Quality-of-Life Impact of Primary Treatments for Localized Prostate Cancer in Patients Without Hormonal Treatment. Journal of Clinical Oncology. 2010;28(31):4687-96. 8. Smith DP, King MT, Egger S, Berry MP, Stricker PD, Cozzi P, et al. Quality of life three years after diagnosis of localised prostate cancer: population based cohort study. BMJ. 2009;339. 9. Punnen S, Cowan JE, Chan JM, Carroll PR, Cooperberg MR. Long-term Health-related Quality of Life After Primary Treatment for Localized Prostate Cancer: Results from the CaPSURE Registry. European Urology. 2015;68(4):600-8. 10. Drummond FJ, Kinnear H, O’Leary E, Donnelly, Gavin A, Sharp L. Long-term health-related quality of life of prostate cancer survivors varies by primary treatment. Results from the PiCTure (Prostate Cancer Treatment, your experience) study. Journal of Cancer Survivorship. 2015;9(2):361-72. 11. Mols F, Korfage IJ, Vingerhoets AJJM, Kil PJM, Coebergh JWW, Essink-Bot M-L, et al. Bowel, Urinary, and Sexual Problems Among Long-Term Prostate Cancer Survivors: A Population- Based Study. International Journal of Radiation Oncology*Biology*Physics. 2009;73(1):30-8. 12. Cooperberg MR, Carroll PR, Klotz L. Active Surveillance for Prostate Cancer: Progress and Promise. Journal of Clinical Oncology. 2011;29(27):3669-76. 13. Bellardita L, Valdagni R, van den Bergh R, Randsdorp H, Repetto C, Venderbos LDF, et al. How Does Active Surveillance for Prostate Cancer Affect Quality of Life? A Systematic Review. European Urology. 2015;67(4):637-45.

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