Rick Schreurs

121 Left and right ventricular response to CRT CONCLUSION The LV and the RV respond in an opposite manner to LV or RV pre-excitation. LV pre- excitation improved LV contractility and decreased RV contractility, while RV pre-excitation had the opposite effects. The CircAdapt computer model realistically captures these opposite responses of LV and RV contractile function. Computer simulations extend animal experimental findings by revealing that improving ventricular contractility does not necessarily lead to an improvement of cardiac output. This study demonstrates the potential of CircAdapt to provide a valuable and efficient in silico platform for further optimization studies for device therapy. 6