Rick Schreurs

147 Impact chapter 6 animal data were the base for computer simulations showing that RV function is important for overall cardiac function. And the results from the animal study in chapter 4 have already been replicated using the CircAdapt software, as well. This shows that computer models have a future in pacemaker research. They can be used in hypothesis generation or help in simulating experiments that are not possible in humans or animals. Multidisciplinary collaboration between cardiologists, physiologists and biomedical engineers, is key to gain the optimal result from computer modeling and simulation. Currently, data from animal and experimental work is still necessary for the development, validation and improvement of models, like the CircAdapt model. On the other hand, these computer models can help to reduce the number of animal and clinical studies by improving hypotheses and gaining more accurate inside in hemodynamics. It is to be expected that in this field the number of animal experiments can decrease over time, while the contribution of computer models will increase. I