Rick Schreurs

TABLE OF CONTENTS CHAPTER 1 General introduction 7 CHAPTER 2 Exploring the electrophysiological and hemodynamic effects of cardiac resynchronization therapy. From bench to bedside and vice versa. 21 CHAPTER 3 Atrioventricular dromotropathy as substrate for successful pacing therapy in heart failure patients: a combined computational-experimental-clinical study 37 CHAPTER 4 Effective mechanical atrioventricular delay covers the impact of various pacing modes on cardiac pump function 61 CHAPTER 5 Pathophysiological interpretation of SonR sensor signals for resynchronization therapy 83 CHAPTER 6 The left and right ventricle respond differently to variation of pacing delays in cardiac resynchronization therapy. A combined experimental-computational approach 105 CHAPTER 7 General discussion 127 Impact 143 Summary/Samenvatting 151 Dankwoord 163 About the author 171