Rick Schreurs

88 Chapter 5 Table 1. Overall and hemodynamic baseline characteristics at the beginning of the final experiment for non-responding and responding animals after the induction of cardiac failure Non-Responders Responders NResp1 NResp2 NResp3 NResp4 Mean± SEM Resp1 Resp 2 Resp3 Resp4 Resp5 Mean± SEM Model AVB RVP LBBB iLBBB LBBB AVB RVP LBBB LBBB tLBBB LBBB Heart failure TP TP TP Spon TP TP TP Iso Iso PR (ms) 150 170 180 110 153±18 150 165 175 115 160 153±12 QRS (ms) 100 88 80 94 91±4 134 138 89 95 100 112±10 LVP max (mmHg) 94 72 120 98 96±10 83 106 117 95 74 95±8 LVEDP (mmHg) 9 30 7 12 15±5 6 28 16 11 11 14±4 LV dP/dt max (mmHg/s) 979 551 1819 843 1048±272 785 918 1370 916 965 991±99 Response at AV opt (%LVdP/dt max ) 7.9 -0.2 -1.3 0.0 +2.4±2.2 20.8 35.1 12.6 10.1 11.0 17.9±4.7* RV dP/dt max (mmHg/s) 289 302 369 222 296±30 291 323 387 302 349 330±17 MIVD (ms) -4 -8 -19 -20 -13±4 -34 -37 -21 -37 -32 -33±3* RA SonR1 (mG) 402 311 334 179 306±47 201 154 78 225 172 166±25* RV SonR1 (mG) 924 161 740 435 566±168 141 688 139 410 390 354±102 AVB: atrioventricular block, RVP: right ventricular pacing, LBBB: left bundle branch block, iLBBB: incomplete LBBB, tLBBB: temporary LBBB, TP: tachypacing, Spon: spontaneous, Iso: Isoflurane, LVPmax: maximal LV pressure, LVEDP: LV end diastolic pressure, BiV: biventricular, LV: left ventricle, RV: right ventricle, MIVD: mechanical interventricular dyssynchrony. * P <0.05 compared to non-responding animals