Timo Soeterik

127 Development of a novel EPE nomogram TABLE 3. Multivariable logistic regression outcomes of four different models Model 1 OR (95% CI) p Model 2 OR (95% CI) p Model 3 OR (95% CI) p Model 4 OR (95% CI) p PSA density 1.64 (0.93 – 2.90) 0.086 2.27 (1.31 – 3.94) 0.004 1.76 (0.99 – 3.10) 0.052 1.70 (0.96 – 3.02) 0.071 DRE T-stage T1 T2 T3 Referent 2.66 (1.96 - 3.60) 5.08 (2.71 - 9.53) <0.001 <0.001 - - - - Referent 1.97 (1.43 – 2.72) 3.32 (1.70 – 6.48) <0.001 <0.001 MRI No lesion Organ-confined EPE - - Referent 2.36 (1.71 - 3.25) 8.45 (5.79 - 12.32) <0.001 <0.001 Referent 2.22 (1.60 – 3.08) 6.90 (4.67 - 10.21) <0.001 <0.001 Referent 1.96 (1.40 – 2.73) 5.22 (3.47 – 7.87) <0.001 <0.001 ISUP Grade Benign 1 2 3 4 5 Referent 0.89 (0.52 – 1.54) 1.99 (1.17 – 3.39) 2.60 (1.44 - 4.70) 3.36 (1.86 - 6.05) 4.94 (2.53 - 9.62) 0.7 0.012 0.001 <0.001 <0.001 Referent 1.48 (0.92 - 2.38) 3.03 (1.94 - 4.74) 4.46 (2.66 - 7.46) 5.99 (3.47 – 10.3) 9.92 (5.62 - 17.5) 0.11 <0.001 <0.001 <0.001 <0.001 Referent 0.74 (0.43 – 1.27) 1.30 (0.76 – 2.22) 1.94 (1.08 – 3.48) 2.79 (1.52 – 5.14) 3.66 (1.88 - 7.13) 0.3 0.4 0.027 0.001 <0.001 Referent 0.80 (0.46 - 1.38) 1.44 (0.83 – 2.49) 1.90 (1.04 – 3.48) 2.62 (1.41 – 4.86) 3.63 (1.92 – 7.21) 0.4 0.19 0.036 0.002 <0.001 % Positive cores 4.75 (2.83 - 7.94) <0.001 - - 4.77 (2.83 – 8.00) <0.001 3.84 (2.25 – 6.53) <0.001 AUC 0.80 (0.69 – 0.87) 0.80 (0.70 – 0.87) 0.81 (0.71 – 0.88) 0.82 (0.72 – 0.89) Hosmer and Lemeshow p 0.65 0.59 0.78 0.99 7