Timo Soeterik

CONTENTS Chapter 1 General Introduction and Thesis Outline 9 Part I. Optimising Active Surveill ance Chapter 2 A ctive Surveillance for Prostate Cancer in a Real-life Cohort: Comparing Outcomes for PRIAS-eligible and PRIAS-ineligible Patients European Urology Oncology, 2018 29 Chapter 3 Follow-up in Active Surveillance for Prostate Cancer: Strict Protocol Adherence Remains Important for PRIAS-ineligible Patients European Urology Oncology, 2019 43 Part II. Impact of MRI on Prostate Cancer Risk Classification Chapter 4 M ultiparametric Magnetic Resonance Imaging Should Be Preferred Over Digital Rectal Examination for Prostate Cancer Local Staging and Disease Risk Classification Urology, 2021 61 Part III. Association Between Nerve Sparing and Positive Surgical Margins Chapter 5 Nerve sparing during Robot-Assisted Radical Prostatectomy Increases the Risk of Ipsilateral Positive Surgical Margins The Journal of Urology, 2020 85 Part IV. Incorporation of MRI into Clinical Prediction Models Chapter 6 External Validation of the Martini nomogram for Prediction of Side- Specific Extraprostatic Extension of Prostate Cancer in Patients Undergoing Robot-Assisted Radical Prostatectomy Urologic Oncology: Seminars and Original Investigations, 2019 103 Chapter 7 D evelopment and External Validation of a Novel Nomogram to Predict Side-Specific Extraprostatic Extension in Patients with Prostate Cancer Undergoing Radical Prostatectomy European Urology Oncology, 2020 119 Chapter 8 E xternal validation of the MSKCC and Briganti Nomograms For Prediction of Lymph Node Involvement of Prostate Cancer Using Clinical Stage Assessed by Magnetic Resonance Imaging British Journal of Urology International, 2021 139 Part V. Summary and General Discussion Chapter 9 General Summary 161 Chapter 10 General Discussion and Future Perspectives 167 Appendices Dutch Summary - Nederlandse Samenvatting Authors and Affiliations Review Committee List of publications Curriculum Vitae Auctoris Dankwoord 180 184 185 186 188 189