Timo Soeterik

80 CHAPTER 4 SUPPLEMENTARY TABLE S5. Diagnostic accuracy for the detection of non-organ-confined disease of pre- and post-biopsy mpMRI mpMRI timepoint Sensitivity (%) Specificity (%) PPV (%) N PV (%) Accuracy (95% CI) Pre-biopsy 63/133 (47) 140/210 (85) 63/87 (72) 140/210 (67) 0.66 Post-biopsy 56/82 (55) 82/127 (76) 56/82 (68) 82/127 (65) 0.66 SUPPLEMENTARY TABLE S6. Concordance of risk group classification with final surgical pathology Risk group based on surgical pathology ( N = 426) Based on DRE N (%) Based on mpMRI N (%) Low-risk ( N = 2) Low-risk 1 (50) 1 (50) Intermediate 1 (50) 1 (50) Localized high-risk 0 0 Locally advanced high-risk 0 0 Intermediate-risk ( N = 31) Low-risk 4 (13) 3 (10) Intermediate 24 (77) 18 (58) Localized high-risk 3 (10) 6 (19) Locally advanced high-risk 0 (0) 4 (13) Localized high-risk ( N = 151) Low-risk 30 (20) 21 (14) Intermediate 80 (53) 55 (36) Localized high-risk 33 (22) 49 (33) Locally advanced high-risk 8 (5) 26 (17) Locally advanced high-risk ( N = 242) Low-risk 13 (5) 10 (4) Intermediate 102 (42) 45 (19) Localized high-risk 80 (33) 54 (22) Locally advanced high-risk 47 (19) 133 (55) *Total population of patients undergoing RARP analyzed in this study included 506 patients, however, in respectively 80 patients no pT2 sub classification (T2a, T2b or T2c) was reported.