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21 GENERAL INTRODUCTION 1 Robertson, M. A., Kau, C. H., English, J. D., Lee, R. P., Powers, J. and Nguyen, J. T. (2011) ‘MI Paste Plus ® to prevent demineralization in orthodontic patients: a prospective randomized controlled trial’, Am J Orthod Dentofacial Orthop , 140(5), pp. 660-8. Rose, R. K. (2000) ‘Binding characteristics of Streptococcus mutans for calcium and casein phosphopeptide’, Caries Res , 34(5), pp. 427-31. Senestraro, S. V., Crowe, J. J., Wang, M., Vo, A., Huang, G., Ferracane, J. and Covell, D. A., Jr. (2013) ‘Minimally invasive resin infiltration of arrested white-spot lesions: a randomized clinical trial’, J Am Dent Assoc , 144(9), pp. 997-1005. Shafi, I. (2008) ‘No evidence to support one surgical technique over the other for the management of palatally displaced canines’, Evid Based Dent , 9(4), p. 111. Shungin, D., Olsson, A. I. and Persson, M. (2010) ‘Orthodontic treatment-related white spot lesions: a14-year prospectivequantitative follow-up, includingbondingmaterial assessment’, Am J Orthod Dentofacial Orthop , 138(2), pp. 136 e1-8; discussion 136-7. Stecksen-Blicks, C., Renfors, G., Oscarson, N. D., Bergstrand, F. and Twetman, S. (2007) ‘Caries-preventive effectiveness of a fluoride varnish: a randomized controlled trial in adolescents with fixed orthodontic appliances’, Caries Res , 41(6), pp. 455-9. Sudjalim, T. R., Woods, M. G. and Manton, D. J. (2006) ‘Prevention of white spot lesions in orthodontic practice: a contemporary review’, Aust Dent J , 51(4), pp. 284-9; quiz 347. Sundell, A. L., Ullbro, C. and Koch, G. (2013) ‘Evaluation of preventive programs in high caries active preschool children’, Swed Dent J , 37(1), pp. 23-9. ten Cate, J. M. and Arends, J. (1980) ‘Remineralization of artificial enamel lesions in vitro: III. A study of the deposition mechanism’, Caries Res , 14(6), pp. 351-8. Tranaeus, S., Shi, X. Q. and Angmar-Mansson, B. (2005) ‘Caries risk assessment: methods available to clinicians for caries detection’, Community Dent Oral Epidemiol , 33(4), pp. 265-73. van der Kaaij, N. C., van der Veen, M. H., van der Kaaij, M. A. and ten Cate, J. M. (2015) ‘A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in orthodontic patients’, Eur J Oral Sci , 123(3), pp. 186-93. Wenzel, A., Larsen, M. J. and Fejerskov, O. (1991) ‘Detection of occlusal caries without cavitation by visual inspection, film radiographs, xeroradiographs, and digitized radiographs’, Caries Res , 25(5), pp. 365-71. Willmot, D. R. (2004) ‘White lesions after orthodontic treatment: does low fluoride make a difference?’, J Orthod , 31(3), pp. 235-42; discussion 202. Yengopal, V. and Mickenautsch, S. (2009) ‘Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis’, Acta Odontol Scand, 67(6), pp. 321-32. Zero, D. T. (2006) ‘Dentifrices, mouthwashes, and remineralization/caries arrestment strategies’, BMC Oral Health, 6 Suppl 1, p. S9.

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