M Beerens

78 CHAPTER 5 ABSTRACT Background Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACPF) can remineralise subsurface lesions of enamel, so called white spot lesions (WSL). It is theactive ingredientofMI PastePlus ® . The long-termremineralisation efficacy is unknown. Objective To evaluate the long-term effect of MI Paste Plus ® versus a control paste on remineralisation of enamel after fixed orthodontic treatment over a 12-month period. Design This trial was designed as a prospective, double-blinded, placebo-controlled, randomised clinical trial. Methods Patients with subsurface lesions scheduled for removal of the appliance were included. They applied either MI Paste Plus ® or control paste once a day at bedtime for 12 months, complementary to normal oral hygiene. Main outcome measures Changes in enamel lesions (primary outcome), fluorescence loss and lesion area were determined by quantitative light-induced fluorescence (QLF). Secondary outcomes were microbial composition (by conventional plating with petri dishes), and acidogenicity of plaque (by capillary ion analysis (CIA)), and lesion changes scored visually on clinical photographs. Randomization Participants [age=15.5 years (SD=1.6)] were randomly assigned toeither theMI Paste Plus ® or the control group, as determined by a computer-randomization scheme, created and locked before the start of the study. Participants received neutral-coloured concealed toothpaste tubes marked A or B.