M Beerens

EFFECTS OF MI PASTE PLUS ® : A 12-MONTHS FOLLOW-UP 5 79 Blinding The patients and the observers were blinded with respect to the content of tube A or B. Results A total of 51 patients were analysed; MI Paste Plus ® ( n = 25) versus control group ( n = 26) (14 patients of the original 65 patients dropped out). There was no significant difference between the groups over time for all the used outcome measures. There was a significant improvement in enamel lesions (fluorescence loss) over time in both groups ( P < 0.001 and P < 0.001), with no differences between groups. Limitations Being an in vivo study, non-compliance of the subjects could have influenced the result. Conclusion The additional use of MI Paste Plus ® in patients with subsurface enamel lesions after orthodontic fixed appliance treatment did not improve these lesions during the 1 year following debonding. Registration This trial is registered at the medical ethical committee of the VU Medical Centre in Amsterdam (NL.199226.029.07).