15283-B-Blokker

205 A expression analyses. If MIA were to be implemented in clinical practice, it creates an opportunity to obtain more tissue samples of (recurred) primary cancer processes and their metastases, which are required to examine intra-tumor heterogeneity, to further develop cancer therapies. Because post-mortem imaging is quite a new field in clinical radiology, we evaluated the occurrence of common post-mortem changes (due to chemical and physical processes in the deceased’s body), which presented on the MRI and CT scans within our cohort. The study in chapter 8 shows that decomposition-related changes increased with the post-mortem time interval. Intravascular air, pleural effusion, periportal edema, and distended intestines occurred more frequently after resuscitation, and post- mortem clotting less frequently; distended intestines and loss of grey-white matter differentiation in the brain were correlated with post-mortem time interval; and hyperdense cerebral vessels, subcutaneous edema, fluid in the abdomen and internal livores of the liver were more frequently seen in ICU patients. In the future, for MIA to be implemented in clinical practice, radiologists need in-depth understanding of these processes for correct acquisition and interpretation of the post-mortem scans. Summary