15289-s-bos

7 109 | Latest developments in the treatment of lipoprotein (a) Table 7.1 | Overview of different drugs and their effects op Lp(a) levels Compound Effect Lp(a) * Effect other lipoproteints Dicussed study on effect Lp(a) Assay used in discussed study Effect cardiovascular events Conclusion Lifestyle None Decrease TG variable Decrease LDL-C variable Increase HDL-C variable Langsted et al. [11] Diasys and Denka Seiken Decrease No effect on Lp(a) Improves lipoprotein profile Decreases cardiovascular events (observational studies) Oestrogen Decrease 23-25% (Increase 106% when blocking Oestrogen with Letrozole) Decrease LDL-C 14% Increase TG 10% Increase HDL-C 8% Howard and Rossouw [12] (The Woman’s Health Initiative) Unknown No effect Decreases Lp(a) Improves lipoprotein profile No effect on cardiovascular events Studied in women only Eprotirome Decrease 43% Decrease LDL-C 32% Decrease TG 33% Shoemaker et al. [15] Tinaquant (Roche) Unknown Decreases Lp(a) Improves lipoprotein profile Program terminated due to safety issues Statins If present at all not clinically significant Decrease LDL-C 36- 38% Decrease TG 7-12% Increase HDL-C 11- 12% Kim et al. [21] Tinaquant (Roche) Decrease No effect on Lp(a) Improves lipoprotein profile Decreases cardiovascular events Recommended for treatment of Lp(a)-Hyperlipoproteinemia