15289-s-bos

8 125 | Novel protein biomarker predictors of CAD in FH severity and other disease characteristics with the proteins was conducted using a tobit regression model with truncation at zero. 29 Statistical significance was determined by a p-value less than 0.05 for the multivariate models. All analysis was conducted using the Stata package (Version 13.1, StataCorp, College Station, Tx, USA). Results Patient characteristics The patient characteristics are presented in Table 1. There was a significant difference in mean age between the groups in addition to a higher number of male patients. Approximately three quarters of the participants had a family history of CAD, while one third had known hypertension. There were no significant differences in fasting glucose levels between the groups (data not shown) and there were only 2 subjects with diabetes (both in the FH + Ca group). Thirty percent of the cohort were current or ex smokers and there were significantly more in the FH + CAD group (70% (46-86) vs. 30% (13-54), p=0.004). As expected, the FH patients with low atherosclerotic burden (FH) had a significantly lower mean calcium score compared with the FH patients with high atherosclerotic burden (FH + Ca) (1.96 (1.18, 3.26) v 590.4 (408.8, 582,8), p=0.0001). Table 8.1 | Patient characteristics FH only FH + Ca FH + CAD Total p N 20 19 20 Age (yrs) 46.1 (43.6, 48.6) 55.2 (51.4, 58.9) 57.3 (52.3, 62.3) 0.0005 Gender n (%) n (%) n (%) • Male • Female 11 (32.4) 9 (36.0) 14 (41.2) 5 (20.0) 9 (26.5) 11 (44.0) 34 (100) 25 (100) 0.186 Hypertension • No • Yes 19 (40.4) 1 (8.3) 12 (25.5) 7 (58.3) 16 (34.0) 4 (33.3) 47 (100) 12 (100) 0.047 Family History • No • Yes 5 (33.3) 15 (34.1) 5 (33.3) 14 (31.8) 5 (33.3) 15 (34.1) 15 (100) 44 (100) 0.994 Smoker • Never • Former • Current 11 (33.3) 6 (50.0) 3 (21.4) 16 (48.5) 3 (25.0) 0 (0) 6 (18.2) 3 (25.0) 11 (78.6) 33 (100) 12 (100) 14 (100) 0.001