15289-s-bos

8 127 | Novel protein biomarker predictors of CAD in FH with the exception of CD14. Not all proteins could be detected in a substantial proportion of participants; in particular, monocyte differentiation antigen (CD14) was not detected in more than 75% of the participants, including none of the FH + CAD patients. Within the whole cohort, there were significant associations between gender and C4B (Mann-Whitney Z=2.31, p=0.021), C1QB (Z=2.49, p=0.013), CD14 (Z=2.17, p=0.03) and HRG (Z=2.14, p=0.033). There were also significant associations between smoking and LRG1 (Kruskal-Wallis χ 2 2 =6.59, p=0.037), CB4 (χ 2 2 =7.85, p=0.02) and HRG (χ 2 2 =6.11, p=0.047). There were no significant associations between any of the protein biomarkers and age or lipid levels. Figure 8.1 | Relative abundance of plasma protein biomarkers in all patients with familial hypercholesterolemia. Analysis of protein biomarkers as indicators of CAD Table 2 shows the results of the OC regression analysis for the level of each protein and also for the total number of proteins that could be detected. Crude HRs were generally lower than the adjustedHR, which reflects the increase in risk of coronary atherosclerosis and CAD with increasing age and with smoking. Two p values are shown in the table, the first tests the null hypothesis that the HR across the groups is equal (HR=1) and the second tests the null hypothesis that the change in the HR is the same for each transition from FH to FH + Ca to FH + CAD. Overall, it is clear that all of the peptides were significantly associated with progression of CAD, independently of age and smoking exposure, using a critical p value adjusted for multiple comparisons.