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128 | Chapter 8 Table 8.2a | Univariate CAD HR models for group by each peptide Peptide Hazard ratio 95% CI for HR p 1 HR=1 p 2 HR=For each group LRG1 0.054 0.017 0.170 <0.001 0.302 ITIH3 0.213 0.094 0.481 <0.001 0.054 C4B 0.005 0.000 0.050 <0.001 0.020 C1QB 0.069 0.021 0.230 <0.001 0.334 CD14 0.149 0.049 0.458 0.001 0.145 HRG 0.132 0.048 0.365 <0.001 0.001 Peptides detected 0.054 0.017 0.170 <0.001 0.302 Table 8.2b | Multivariable CAD HR models for each peptide adjusted for age and smoking status LRG1 0.102 0.028 0.377 0.001 0.003 ITIH3 0.292 0.123 0.692 0.005 0.111 C4B 0.027 0.002 0.416 0.010 <0.001 C1QB 0.142 0.034 0.601 0.008 0.027 CD14 0.222 0.058 0.850 0.028 0.199 HRG 0.262 0.086 0.794 0.018 <0.001 Peptides detected 0.102 0.028 0.377 0.001 0.003 Results are presented as hazard ratios (HR) with 95% Confidence Intervals (95% CI) using continuation ratio regression model before and after adjustment for age and smoking. All of p 1 were statistically significant after correction for multiple comparisons. LRG1 – leucine-rich alpha-2-glycoprotein, ITIH3 – inter-alpha-trypsin inhibitor heavy chain H3, C4B – Complement C4-B, C1QB – Complement C1q subcomponent subunit B, CD14 – Monocyte differentiation antigen, HRG – histidine-rich glycoprotein However, the analysis also showed that it was the absence of the proteins that was the strongest indicator and this is demonstrated in Table 3 where it can be seen that for all proteins, other than CD14, there are few patients in the FH only group who don’t show the protein and there are few in the FH + CAD group who do show the protein. Results of the association between the amount of protein and other CAD severity markers are shown in Table 4. It is clear that the proteins are not associated with clinical indicatorsofCADseverity.Atobittruncatedregressionanalysisdemonstratedasignificant negative association with the Framingham points score for C4B (coefficient=-11.4, p=0.031), C1QB (coefficient=-6.99, p=0.011) and HRG (coefficient=-4.83, p=0.033) in the FH and FH + Ca patients (the only patients for which this was appropriate).