15289-s-bos

8 135 | Novel protein biomarker predictors of CAD in FH Framingham Heart Study support this, as LRG1 was only found to be predictive of new- onset atherosclerosis, and not myocardial infarction. 30 Inflammation plays a key role in both the development and progression of atherosclerosis, with initial modification of LDL resulting in its preferential uptake in the intimal layer of the arterial wall, resulting in an immediate innate immune response, which ultimately leads to the development of fatty lesions and atherosclerotic plaques. 35 Children with FH have been shown to have an inflammatory imbalance, which may contribute to the accelerated atherosclerosis development. 36 Furthermore, oxidative modification of LDL has been shown to be related to inflammatory gene expression and subsequent atherosclerosis development in both children and young adults with FH. 37 Complement C4-B (C4B) and Complement C1q subcomponent subunit B (C1BQ) are part of the complement system, which plays a role in our innate defence. As oxidatively modified LDL promotes inflammation, the innate immune system is the Figure 8.5 | Area under the receiver operating characteristic curve, estimating the predictive accuracy of each protein with coronary artery calcium. AUC: Area under the curve; C1QB: Complement C1q subcomponent subunit B; C4B: Complement C4-B; CAD: Coronary artery disease; CD14: Monocyte differentiation antigen; CI: Confidence interval; HRG: Histidine-rich glycoprotein; ITIH3: Inter-alpha-trypsin inhibitor heavy chain H3; LRG1: Leucine-rich alpha-2-glycoprotein.