15289-s-bos

9 155 | Summary and Discussion 20. Cowell SJ, Newby DE, Prescott RJ et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. The New England journal of medicine 2005;352:2389-97. 21. Viney N, Graham M, Crooke R, Hughes S, Singleton W. Evaluation of Isis APO(A)RX, an antisense inhibitor to apolipoprotein(a), in healthy volunteers. Circulation 2013;128. 22. Sillesen H, Muntendam P, Adourian A et al. Carotid plaque burden as a measure of subclinical atherosclerosis: comparison with other tests for subclinical arterial disease in the High Risk Plaque BioImage study. JACC Cardiovascular imaging 2012;5:681-9. 23. Ershova AI, Balakhonova TV, Meshkov AN, Rozhkova TA, Boytsov SA. Ultrasound markers that describe plaques are more sensitive than mean intima-media thickness in patients with familial hypercholesterolemia. Ultrasound Med Biol 2012;38:417-22. 24. Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet (London, England) 2001;357:577-81. 25. van Wissen S, Smilde TJ, Trip MD, Stalenhoef AF, Kastelein JJ. Long-term safety and efficacy of high- dose atorvastatin treatment in patients with familial hypercholesterolemia. The American journal of cardiology 2005;95:264-6. 26. Awan Z, Alrasadi K, Francis GA et al. Vascular calcifications in homozygote familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology 2008;28:777-85. 27. Hoeg JM, Feuerstein IM, Tucker EE. Detection and quantitation of calcific atherosclerosis by ultrafast computed tomography in children and young adults with homozygous familial hypercholesterolemia. Arteriosclerosis and thrombosis : a journal of vascular biology / AmericanHeart Association 1994;14:1066- 74. 28. Smith JG, Luk K, Schulz CA et al. Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis. Jama 2014. 29. Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 2000;102:1082-5. 30. Erqou S, Kaptoge S, Perry PL et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. Jama 2009;302:412-23.