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Table of Contents Chapter 1 Introduction 7 Chapter 2 Validation of a novel fully-automated ultrasound system for 19 the assessment of carotid intima-media thickness and plaques. (in submission) Chapter 3 Carotid artery plaques and intima medial thickness in familial 31 hypercholesteraemic patients on long-term statin therapy: A case control study Atherosclerosis 2016 Dec;256: 62-66 Chapter 4 Increased aortic valve calcification in familial hypercholesterolemia: 45 Prevalence, extent and associated risk factors in a case-control study J Am Coll Cardiol 2015;66:2687–95 Chapter 4B Calcific Aortic Valve Disease in Familial Hypercholesterolemia: 63 The LDL-Density-Gene Effect Nalini M. Rajamannan, MD Editorial Comment: JACC referring to chapter 4 Chapter 5 Lp(a) is associated with AVC in statin treated FH patients 71 J Intern Med. 2015 Aug;278(2):166-73 Chapter 6 Lp(a) is not associated with subclinical atherosclerosis measured 87 by ultrasound in statin treated FH patients Atherosclerosis. 2015 Sep;242(1):226-9 Chapter 7 Latest developments in the treatment of lipoprotein (a) 99 Current Opinion Lipidology. 2014 Dec;25(6):452-60 Chapter 8 A proteomics approach to discover novel biomarkers of 119 CVD in FH patients Journal of Clinical Lipidology (2017) 11, 682–6939). Chapter 9 Summary and Discussion 143 Appendices Nederlandse samenvatting 159 Dankwoord 163 Curriculum Vitae 169 List of Publications 171 ECTS portfolio 173