15289-s-bos

4 51 | Rebuttal AoVC in FH Table 4.1 | Clinical characteristics He-FH (N = 145) Control (N = 131) p-value General • Age (years) 52 ± 8 56 ± 9 < 0.001 • Gender (male) 93 (64) 78 (60) 0.432 • Body mass index (kg / m²) 27 ± 4 27 ± 5 0.309 • Smoking (current / former) 41 (28) 45 (35) 0.277 • Hypertension 1* 38 (26) 59 (45) 0.001 • Systolic blood pressure (mmHg) 129 ± 7 141 ± 20 < 0.001 • Diastolic blood pressure (mmHg) 80 ± 10 81 ± 12 0.282 • Diabetes Mellitus 6 (4) 17 (13) 0.008 • Positive family history of premature coronary artery disease 2 * 102 (70) 65 (50) < 0.001 Lipids • Maximum untreated total cholesterol (mmol / L) 9.8 ± 2.3 5.5 ± 1.2 < 0.001 • Maximum untreated LDL cholesterol (mmol / L) 7.1 ± 2.2 3.7 ± 1.1 < 0.001 • Statin use 142 (98) 44 (34) < 0.001 • Total cholesterol (mmol / L) 5.5 ± 1.4 5.3 ± 1.2 0.264 • HDL (mmol / L) 1.4 ± 0.4 1.4 ± 0.4 0.388 • LDL (mmol / L) 3.5 ± 1.3 3.5 ± 1.1 0.980 • Triglyceride (mmol / L) 1.09 (0.80 - 1.65) 1.32 (0.87 - 1.79) 0.107 Values are mean SD, n (%), or median (interquartile range). 1*Blood pressure >140/90 mm Hg and/or antihypertensive treatment. 2*Proven coronary artery disease in first-degree relative aged <60 years. Control = patients with nonanginal chest pain; HDL = high density lipoprotein; he-FH = heterozygous familial hypercholesterolemia; LDL = low-density lipoprotein; LDL-C = low-density lipoprotein cholesterol. Table 4.2 | Calcification of the aortic valve leaflets He-FH (N = 145) Control (N = 131) p-value AoVC present AoVC present, per age category: 59 (41%) 27 (21%) < 0.001 • 40 - 50 years 16 (26%) 0 (0%) 0.002 • 51 - 58 years 21 (48%) 8 (17%) 0.001 • 59 - 70 years 22 (56%) 19 (36%) 0.005 AoVC-score 51 (9 - 117) 21 (3 - 49) 0.007 AoVC-score per category: < 0.001 • Agatston = 0 86 (59) 104 (79) - • Agatston > 0 – 37 24 (17) 19 (15) - • Agatston > 37 35 (24) 8 (6) - Continuous data are expressed as median (IQR), dichotomous data as N (%), age categories chosen on the basis of equal patient numbers in all groups (N = 92). He-FH = heterozygous familial hypercholesterolemia, control = patients with non-anginal chest pain. AoVC = aortic valve calcification, AoVC-score categories chosen on the basis of equal distribution of patients with AoVC (N = 43).