15289-s-bos

4 59 | Rebuttal AoVC in FH Perspectives Clinical Competency: This is the first study that shows a high prevalence and extent of aortic valve calcification in he-FH patients. With the prolonging survival in these patients due to statin treatment, and its lacking effect in halting the progression of AoVC, our study results suggest that aortic valve pathology will be a common problem in the aging he-FH patient. Translational Outlook: The mechanism by which LDL-C initiates AoVC requires furthers investigation. Translational Outlook 2: Prospective imaging studies of aging he-FH patients are needed to elucidate the clinical outcome of aortic valve pathologies in these patients.