15289-s-bos

5 77 | Lp(a) and AoVC in FH Table 5.1 | General characteristics of the study population n 129 Male (n, %) 81 (62.8%) Age (y) 51 (46-59) Systolic blood pressure (mmHg) 129+12 Diastolic blood pressure (mmHg) 80+8 BMI (kg/m2) 26.3+3.7 Total cholesterol (mmol/L) 5.47+1.41 LDL-cholesterol (mmol/L) 3.49+1.24 HDL-cholesterol (mmol/L) 1.38+0.37 Triglyceride (mmol/L) 1.05 (0.78-1.55) Fasting blood sugar (mmol/L) 5.31+0.69 Lipoprotein(a) (mg/dL) 26.7 (8.1-63.9) Statin medication (n, %) 126 (97.7%) Duration of statin use (y) 7 (2-14) Previous and current smoker (n, %) 33 (25.6%) Hypertension (n, %) * 34 (26.4%) Bicuspid aortic valve (n, %) 0 (0%) Aortic valve calcium (n, %) 0 AU 79 (61.2%) > 0 – 100 AU 38 (29.5%) > 100 – 400 AU 9 (7.0%) > 400 AU 3 (2.3%) Coronary artery calcium (n, %) 0 AU 27 (20.9%) > 0 – 100 AU 45 (34.9%) > 100 – 400 AU 29 (22.5%) > 400 AU 28 (21.7%) * Hypertension: SBP >140mmHg and/or DBP > 90 mmHg or the use of antihypertensive medication. Association between Lp(a) and CVD-related parameters Lp(a) concentrations were positively correlated with gender (r = 0.20, p = 0.02), as female FH patients had higher Lp(a) concentrations than male patients (35.5(11.7-74.8) vs. 19.7(4.3-50.5) mg/dL, p = 0.02). In contrast, no significant associations were found between Lp(a) concentrations and the presence (r = 0.05, p = 0.56) or severity (r = 0.09, p = 0.32) of CAC. After adjustment for CAC, Lp(a) concentrations remained positively correlated with the presence of AVC (r = 0.19, p = 0.03) but not with the severity of AVC (r