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78 | Chapter 5 = -0.02, p = 0.82). No significant correlations were found between Lp(a) concentrations and age, BMI, blood pressure, smoking or other lipid parameters. Association of AVC with Lp(a) and other CVD parameters Next we analyzed the significant predictors for the presence of AVC using logistic regression analysis (table 2). In a univariate model, age, BMI, blood pressure, duration of statin use, CYS, CAC and Lp(a) concentrations were found to be significant predictors for AVC. Table 5.2 | Univariate logistic regression analysis of the presence of aortic valve calcification (AVC) in patients with familial hypercholesterolemia (FH). Odds ratio 95%CI p Age (year) 1.10 1.04-1.16 <0.001 Gender (male) 1.67 0.79-3.55 0.18 BMI (kg/m 2 ) 1.11 1.01-1.23 0.04 Systolic blood pressure (mmHg) 1.06 1.02-1.10 0.001 Diastolic blood pressure (mmHg) 1.05 1.01-1.11 0.03 Total cholesterol (mmol/l) 1.15 0.89-1.49 0.28 LDL-cholesterol (mmol/l) 1.34 0.98-1.85 0.07 HDL-cholesterol (mmol/l) 0.90 0.35-2.32 0.82 Triglyceride (mmol/l) 1.04 0.69-1.56 0.86 Fasting blood glucose (mmol/l) 1.26 0.76-2.10 0.37 Lipoprotein(a) (per 10 mg/dL) 1.12 1.04-1.20 0.004 LMW apo(a) phenotype 1.23 0.56-2.72 0.60 Duration of statin use (year) 1.08 1.02-1.13 0.004 Previous and current smoker 0.87 0.38-1.97 0.73 Hypertension 1.35 0.61-3.00 0.46 CYS 1.006 1.003-1.01 <0.001 CAC score (AU) 1.004 1.004-1.005 <0.001 * Hypertension: SBP >140mmHg and/or DBP > 90 mmHg or the use of antihypertensive medication; CYS: cholesterol-year score, was calculated using the formula: Untreated total cholesterol x years without statin treatment + statintreated total cholesterol x years treated with statins; CAC: coronary artery calcification For each continuous parameter, odds ratio was calculated per 1 unit increase, except for Lipoprotein(a). TheindependentassociationofLp(a)concentrationwithAVCwasanalyzedusingmultiple logistic regression analysis with increasing number of parameters for adjustment (table 3). As age, CYS and duration of statin-use were highly mutually correlated, CYS was used