15289-s-bos

Chapter 1 Introduction 7
Chapter 2 Validation of a novel fully-automated ultrasound system for the assessment of carotid intima-media thickness and plaques. (in submission). 19
Chapter 3 Carotid artery plaques and intima medial thickness in familial hypercholesteraemic patients on long-term statin therapy: A case control study 31
Chapter 4 Increased aortic valve calcification in familial hypercholesterolemia: Prevalence, extent and associated risk factors in a case-control study 45
Chapter 4B Calcific Aortic Valve Disease in Familial Hypercholesterolemia: The LDL-Density-Gene Effect 63
Chapter 5 Lp(a) is associated with AVC in statin treated FH patients 71
Chapter 6 Lp(a) is not associated with subclinical atherosclerosis measured by ultrasound in statin treated FH patients 87
Chapter 7 Latest developments in the treatment of lipoprotein (a) 99
Chapter 8 A proteomics approach to discover novel biomarkers of CVD in FH patients 119
Chapter 9 Summary and Discussion 143
Appendices Nederlandse samenvatting 159
Dankwoord 163
Curriculum Vitae 169
List of Publications 171
ECTS portfolio 173

RkJQdWJsaXNoZXIy MTk4NDMw