Wouter Leclercq

Personalised perioperative care by e-health after intermediate-grade abdominal surgery: A multicentre, single-blind, randomised, placebo-controlled trial 169 10 Median time until first return to normal activities was 3 days (IQR 1-5) in the intervention group and 3 days (1-6) in the control group (HR 1.14, 95% CI 0.92–1.42; P=0.229). Median time until 75% of normal activities were resumed differed significantly between study groups (median 13 days [IQR 6-22] in the intervention group vs. 16 days [7-25] in the control group; HR 1.25, 95% CI 1.01-1.56; P=0.046). In the subsample of participants who were employed, time until first resumption of work did not differ between groups (median 14 days [IQR 7-21] in the intervention group vs. 13 days [7-23] in the control group; HR 1.00, 95% CI 0.77-1.29; P=0.983), but time until full resumption of work did differ significantly (median 18 days [IQR 10-27] in the intervention group vs. 19 days [11- 33] in the control group; HR 1.31 95% CI 1.01-1.70; P=0.045). 5 15 6 17 7 20 51 70 Number at risk* Intervention group 163 Control group 167 180 150 120 90 Time since surgery (days) 12 25 24 40 60 30 0 0 Adjusted HR 1.38 (95% CT 1.09-1.73); p=0·007 20 40 60 100 Intervention group Control group 80 Return to normal activities (%) Figure 10.3 Time to return to normal activities after surgery. HR=hazard ratio. *Number at risk is the number of participants allocated to the group, minus the number who dropped out, minus the number who already reached the outcome event (return to normal activities). Correcting these analyses for return to work expectations, which differed between groups at baseline, did not change the results by much (data not shown). Other secondary outcomes are presented in Table 10.3. None of the outcome measures showed a significant interaction with time, so the presented differences represent the mean differences averaged over the follow-up period. Social participation scores and physical function scores were significantly higher during follow-up in the intervention group compared with the control group. Other outcome measures did not differ between groups.