Wouter Leclercq

Personalised perioperative care by e-health after intermediate-grade abdominal surgery: A multicentre, single-blind, randomised, placebo-controlled trial 171 10 Table 10.3 Secondary outcome measures. Outcome measure timepoint β * (95% CI) p-value Physical function (PROMIS-PF) T1, T2, T3, T4, T5 1.22 (0.16 to 2.27) 0.024 Social participation (PROMIS-APS) T1, T2, T3, T5 1.44 (0.15 to 2.72) 0.038 Self-rated health (EQ-5D-3L) T2, T3, T4, T5 1.62 (–3.33 to 6.57) 0.520 Physical activities (IPAQ) T1, T2, T3 5.87 (–13.12 to 24.87) 0.543 Recovery (RI5) T1, T2, T3, T4, T5 0.17 (–0.41 to 0.76) 0.559 Pain intensity (VAS) T1, T2, T3 –0.49 (–1.59 to 0.61) 0.379 Mixed-model analyses using all outcome measure timepoints after surgery on which outcomes were assessed. Corrected for baseline scores measured the month before surgery, except pain variables because they were not measured at baseline. PROMIS=Dutch–Flemish Patient-Reported Outcomes Measurement Information System. PROMIS-PF=PROMIS Physical Function personalised short form. PROMIS-APS=PROMIS Ability to Participate in Social Roles and Activities short form. EQ-5D-3L=EuroQol five dimensions three levels. IPAQ=International Physical Activity Questionnaire. RI5=Recovery Index short version form. VAS=visual analogue scale. T1=1 week after surgery. T2=3 weeks after surgery. T3=6 weeks after surgery. T4=3 months after surgery. T5=6 months after surgery. *Intervention relative to control group. Interactions between group and time were not significant and β values for the main effect for the group after removing the interaction from the model are presented. Participants in the intervention group gave a higher rating to the care programme they had access to than did participants in the control group (mean satisfaction score 7.2 [SD 1.7] vs. 6.3 [2.4]; P=0.001). Satisfaction with overall received care did not differ between study groups (mean score 7.5 [SD 1.7] for the intervention group vs. 7.1 [2.3] for the control group; P=0.169). Total healthcare costs were €202 higher in the intervention group (€926 [SEM 124] for the intervention care programme vs. €721 [90] for the control programme), but this difference was not significant (95% CI –58 to 486; Table 10.4). The difference in QALYs between both groups was small (mean 0.46 [SEM 0·004] in the intervention group vs. 0.45 [0.004] in the control group; difference 0.01, 95% CI 0.0003–0.02).