Lisette van Dam

CTPP for short-term clinical outcome prediction in acute PE 10 159 than chance if AUC=0.5. Calibration was assessed using the Brier score, which ranges from 0 to 0.25, with a score of zero signifies a perfect prediction model and a score of 0.25 a non-informative model. 21 The correlation between PDS and total thrombus load was evaluated using the Pearson’s correlation test. A two-sided p-value of p < 0.05 was considered as statistically significant. All statistical analyses were performed in SPSS version 25 (IBM, Armonk, NY, USA). RESULTS Study population A total of 100 patients with CTPA proven acute PE were eligible for analysis. The baseline characteristics of the 100 included patients are shown in Table 1 . Four patients were transferred to another hospital within 48 hours because of logistical reasons. Results for adverse short-term outcome were thus available for 96 patients. The mean PDS of all included patients was 27% (SD 13%) and mean Qanadli score was 30% (SD 23%). Fourty-nine patients (49%) had a RV/LV ratio > 1 ( Table 1 ). The agreement in PDS scoring between the two reviewers was good with a mean difference in PDS of 4.2% (SD 6.9%). Table 1 . Baseline characteristics of 100 patients with acute pulmonary embolism (PE) Mean age (+/- SD) – years 62 (16) Male – no (%) 53 (53) Median duration of complaints (IQR) – days 2.0 (1-7) Recurrent VTE – no (%) 17 (17) Active malignancy – no (%) 27 (27) Immobility for > 3 days or recent long travel > 6 hours in the past 4 weeks – no (%) 24 (24) Trauma/surgery during the past 4 weeks – no (%) 22 (22) Active inflammation/infection 3 (3) Hormone (replacement) therapy – no (%) 7 (7) Known genetic thrombophilia – no (%) 0 (0) Outpatient 80 (80) Mean PDS score (+/- SD) – percentage 27 (13) Mean Qanadli score (+/- SD) – percentage 30 (23) RV/LV ratio > 1 – no (%) 49 (49) IQR, interquartile range; PDS, perfusion defect score; RV/LV ratio, right ventricle to left ventricle diameter ratio; SD, standard deviation; VTE, venous thromboembolism.