Lisette van Dam

CTPP for short-term clinical outcome prediction in acute PE 10 161 Secondary outcome The results from logistic regression and likelihood-ratio test are shown in Table 3 . The first model including CTPA parameters alone was correlated to ICU admission ( χ 2 = 17.1, degrees if freedin (d.f.) =3, p=0.001). Model 2 was also correlated to ICU admission ( χ 2 = 17.9, d.f.=4, p=0.001), but the predictive capacity hardly improved when PDS was added to CTPA parameters ( χ 2 = 0.799, d.f.=1, p=0.371). Model 1 including CTPA parameters and model 2 with addition of PDS assessment were both able to predict reperfusion therapy ( χ 2 = 20.9, d.f.=3, p < 0.001 and χ 2 = 24.1, d.f.=4, p < 0.001, respectively). However, the predictive capacity of the model did not improve when PDS was added to CPTA parameters ( χ 2 = 3.22, d.f.=1, p=0.073). Model 1 including CTPA parameters alone was able to predict PE-related mortality ( χ 2 = 13.8, d.f.=3, p=0.003). Model 2 was also able to predict PE-related mortality ( χ 2 = 19.3, d.f.=4, p=0.001) and the addition of PDS scoring also increased the predictive capacity of the model ( χ 2 = 5.44, d.f.=1, p=0.020). The odds ratios including 95%CI of each CTPA parameter and PDS within prediction model 2 for each adverse outcome are provided in Table 3 . The AUC for CTPA parameters to predict ICU admission was 0.852 (95%CI 0.647- 1.00), 0.976 (95%CI 0.938-1.00) for reperfusion therapy and 0.989 (95%CI 0.965- 1.00) for PE-related mortality. When PDS was added to the prediction model these AUCs were 0.876 (95%CI 0.725-1.00), 0.984 (95%CI 0.951-1.00) and 1.00 (95%CI 1.00-1.00), respectively ( Table 3 ). The prediction model including CTPA parameters had a Brier score of 0.042 for ICU admission, 0.021 for reperfusion therapy and 0.010 for PE-related mortality. Prediction model 2 had a Brier score of 0.043 for predicting ICU admission, 0.013 for reperfusion therapy and < 0.001 for PE-related mortality ( Table 3 ). With the use of the Pearson correlation test, a positive correlation between the total PDS and CTPA-assessed total thrombus load was found (r = 0.523, p < 0.001).