Lisette van Dam

Clinical and CT characteristics of COVID-19 associated PE 12 185 radiologist was not possible as typical COVID-19 lesions can be seen in patients with COVID-19 infection. Our data suggest that the phenotype of PE in COVID-19 patients may be different from the PE phenotype in patients without COVID-19 pneumonia. Since pulmonary emboli in COVID-19 associated PE patients are more located in the peripheral lung segments and are less extensive compared to PE in patients without COVID-19, COVID-19 associated PE more likely represents a combination of thromboembolic disease and in situ thrombosis. Further investigations, including laboratory studies, are needed to explore the true causal relation between COVID-19 pneumonia and PE or in situ immunothrombosis. Exact knowledge of the origin of PE in COVID-19 patients has important therapeutic consequences since the effect of (prophylactic) anticoagulation on in situ thrombosis is largely unknown. Table 1 . Characteristics of pulmonary embolism (PE) patients with and without COVID-19 PE patients with COVID-19 (n = 23) PE patients without COVID-19 (n = 100) Characteristics and venous thromboembolism (VTE) risk factors Mean age (±SD) – years 63 (6.4) 62 (16) Male sex – n (%) 16 (70) 53 (53) Previous VTE – n (%) 1 (4) 17 (17) Active malignancy – n (%) 1 (4) 27 (27) Trauma/surgery during the past 4 weeks – n (%) 0 (0) 22 (22) Clinical presentation Chest tightness – n (%) 0/4 (0)* 25 (25) Pleural pain – n (%) 0/4 (0)* 55 (55) Dyspnea – n (%) 3/4 (75)* 82 (82) Hemoptysis – n (%) 0 (0) 6 (6.0) Clinical signs of deep vein thrombosis 0 (0) 6 (6.0) D-dimer results (ng/mL) – median (IQR) 7551 (3852-10,005) 2637 (3345-4998) Hemodynamic unstable at diagnosis – n (%) 2 (8.7) 6 (6.0) Reperfusion therapy – n (%) 1 (4.3) 5 (5.0) > 24 hours supplemental oxygen therapy– no (%) 23 (100) 25 (25) Intensive care admission – no (%) 20 (87) 8 (8.0) Radiological presentation Most proximal anatomic location Main/lobar 4 (17) 38 (38) Segmental 16 (70) 41 (41) Subsegmental 3 (13) 11 (11) Qanadli score (%) – mean (SD) 23 (18) 31 (17) Right ventricle diameter (mm) – mean (SD) 43 (8.0) 45 (9.9) Left ventricle diameter (mm) – mean (SD) 44 (7.0) 41 (8.9) RV/LV ratio – mean (SD) 0.97 (0.15) 1.2 (0.38) Pulmonary artery trunk diameter (mm) – mean (%) 29 (4.6) 28 (4.7) *Only for non-sedated non-intubated patients.