Lisette van Dam

Wells rule and D-dimer test in recurrent ipsilateral DVT 4 73 Appendix A . Diagnostic test results of the combination of clinical decision rule (CDR) according (original andmodified) Wells rule and D-dimer testing in suspected recurrent ipsilateral DVT In patients without anticoagulant treatment at baseline: Original Wells rule in combination with D-dimer testing Recurrent DVT No recurrent DVT Total Likely original Wells rule and/or abnormal DD 100 82 182 Unlikely original Wells rule and normal DD 3 46 49 Total 103 128 231 Sensitivity: 97% (95%CI 92-99%) Specificity: 36% (95%CI 28-45%) PPV: 54% (95%CI 51-58%) NPV: 94% (95%CI 83-98%) Modified Wells rule in combination with D-dimer testing Recurrent DVT No recurrent DVT Total Likely modified Wells rule and/or abnormal DD 100 103 203 Unlikely modified Wells rule and normal DD 3 25 28 Total 103 128 231 Sensitivity: 97% (95%CI 92-99%) Specificity: 20% (95%CI 14-27%) PPV: 49 (95%CI 47-52%) NPV: 89% (95%CI 72-96%) In patients with anticoagulant treatment at baseline: Original Wells rule in combination with D-dimer testing Recurrent DVT No recurrent DVT Total Likely original Wells rule and/or abnormal DD 12 22 34 Unlikely original Wells rule and normal DD 2 28 30 Total 14 50 64 Sensitivity: 86% (95%CI 60-96%) Specificity: 56% (95%CI 42-69%) PPV: 35% (95%CI 27-44%) NPV: 93% (95%CI 79-98%)