Mark Wefers Bettink

Measuring mitochondrial oxygenation and respiration in vivo in a human endotoxemia model 6 117 TO T1 T2 T3 0 20 40 60 80 100 MitoPO 2 (mmHg) MitoPO 2 LPS (N=10) Control (N=4) ** Control: P = 0.24 LPS-control: P 0.013 TO T1 T2 T3 -15 -10 -5 0 MitoVO 2 (mmhg*s -1 ) MitoVO 2 LPS (N=10) Control (N=4) # # Control: P = 0.43 LPS: P = 0.033 B. A. Fig 6. Mitochondrial oxygen parameters over time. A. Mitochondrial oxygen concentration (mitoPO 2 ). B. Dynamic mitochondrial oxygen consumption (mitoVO 2 ). Individual curves (control group) and individual data and median values (LPS group) are shown. P-values in panels were calculated using Friedman tests. # P=0.05-0.1 compared with baseline, ** P<0.01 compared with baseline, calculated using Dunn’s post-hoc multiple comparison tests.