Mark Wefers Bettink

Measuring mitochondrial oxygenation and respiration in vivo in a human endotoxemia model 6 121 Key messages frequent monitoring of mitoPO 2 and mitoVO 2 during the day in humans is possible using the noninvasive COMET measurement system. The COMET measurement system can detect changes in mitoPO 2 and, to a lesser extent, mitoVO 2 in a relatively mild model of systemic inflammation in humans. List of abbreviations COMET: Cellular oxygenmetabolism; ALA: 5-Aminolevulinic acid; LPS: Lipopolysaccharide; mitoPO 2 : Mitochondrial oxygen tension; mitoVO 2 : Mitochondrial oxygen consumption; PpIX: Protoporphyrin IX; MAP: mean arterial pressure Declarations Ethics approval and consent to participate The study protocol was approved by the local ethics committee of the Radboud University Nijmegen Medical Centre (CMO 2016-2312) and the Erasmus University Hospital (MEC 2018-090) Consent for publication Participant gave consent to publication for data and images shown. Availability of data and material The dataset generated and/or analyzed during the current study is not publicly available due to subject-related confidentiality, but is available from the corresponding author on reasonable request. Competing interest Dr. E.G. Mik is founder and shareholder of Photonics Healthcare B.V., The company that developed and commercializes the COMET monitor. Photonics Healthcare B.V. holds the exclusive licenses to several patents regarding this technology, filed and owned by the Academic Medical Center in Amsterdam and the Erasmus University Medical Center Rotterdam, the Netherlands. The remaining authors declare that they have no competing interests.