Mark Wefers Bettink

Measuring mitochondrial oxygenation and respiration in vivo in a human endotoxemia model 6 123 References 1. Horan, M.P.; Pichaud, N.; Ballard, J.W.O. Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging. The journals of gerontology. Series A, Biological sciences and medical sciences 2012 , 67 , 1022–1035, doi:10.1093/gerona/glr263. 2. Moore, J.P.R.; Dyson, A.; Singer, M.; Fraser, J. Microcirculatory Dysfunction and Resuscitation: Why, When, and How. British Journal of Anaesthesia 2015 , 115 , 366–375, doi:10.1093/bja/aev163. 3. Puskarich, M.A.; Kline, J.A.; Watts, J.A.; Shirey, K.; Hosler, J.; Jones, A.E. Early Alterations in Platelet Mitochondrial Function Are Associated with Survival and Organ Failure in Patients with Septic Shock. J Crit Care 2016 , 31 , 63–67, doi:10.1016/j.jcrc.2015.10.005. 4. Jeger, V.; Djafarzadeh, S.; Jakob, S.M.; Takala, J. Mitochondrial Function in Sepsis. European journal of clinical investigation 2013 , 43 , 532–542, doi:10.1111/eci.12069. 5. Ince, C.; Mik, E.G. Microcirculatory and Mitochondrial Hypoxia in Sepsis, Shock, and Resuscitation. Journal of applied physiology (Bethesda, Md. : 1985) 2016 , 120 , 226–235, doi:10.1152/ japplphysiol.00298.2015. 6. Mik, E.G. Measuring Mitochondrial Oxygen Tension. Anesthesia Analgesia 2013 , 117 , 834–846, doi:10.1213/ane.0b013e31828f29da. 7. Ubbink, R.; Bettink, M.A.W.; Janse, R.; Harms, F.A.; Johannes, T.; Münker, F.M.; Mik, E.G. A Monitor for Cellular Oxygen METabolism (COMET): Monitoring Tissue Oxygenation at the Mitochondrial Level. Journal of clinical monitoring and computing 2016 , 1–8, doi:10.1007/s10877-016-9966-x. 8. Mik, E.G.; Stap, J.; Sinaasappel, M.; Beek, J.F.; Aten, J.A.; Leeuwen, T.G. van; Ince, C. Mitochondrial PO2 Measured by Delayed Fluorescence of Endogenous Protoporphyrin IX. Nature methods 2006 , 3 , 939–945, doi:10.1038/nmeth940. 9. Harms, F.A.; Bodmer, S.I.A.; Raat, N.J.H.; Mik, E.G. Cutaneous Mitochondrial Respirometry: Non- Invasive Monitoring of Mitochondrial Function. Journal of clinical monitoring and computing 2015 , 29 , 509–519, doi:10.1007/s10877-014-9628-9. 10. Harms, F.A.; Stolker, R.J.; Mik, E. Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers. PloS one 2016 , 11 , e0159544, doi:10.1371/journal.pone.0159544. 11. Baumbach, P.; Neu, C.; Derlien, S.; Bauer, M.; Nisser, M.; Buder, A.; Coldewey, S.M. A Pilot Study of Exercise-Induced Changes in Mitochondrial Oxygen Metabolism Measured by a Cellular Oxygen Metabolism Monitor (PICOMET). Biochimica et biophysica acta. Molecular basis of disease 2018 , doi:10.1016/j.bbadis.2018.12.003. 12. Dorresteijn, M.J.; Eijk, L.T. van; Netea, M.G.; Smits, P.; Hoeven, J.G. van der; Pickkers, P. Iso- Osmolar Prehydration Shifts the Cytokine Response towards a More Anti-Inflammatory Balance in Human Endotoxemia. Innate Immunity 2005 , 11 , 287–293, doi:10.1177/096805190501100505 01. 13. Harms, F.A.; Bodmer, S.I.A.; Raat, N.J.H.; Mik, E.G. Non-Invasive Monitoring of Mitochondrial Oxygenation and Respiration in Critical Illness Using a Novel Technique. Critical care (London, England) 2015 , 19 , 343, doi:10.1186/s13054-015-1056-9. 14. Mik, E.G.; Johannes, T.; Zuurbier, C.J.; Heinen, A.; Houben-Weerts, J.H.P.M.; Balestra, G.M.; Stap, J.; Beek, J.F.; Ince, C. In Vivo Mitochondrial Oxygen Tension Measured by a Delayed Fluorescence Lifetime Technique. Biophysical journal 2008 , 95 , 3977–3990, doi:10.1529/biophysj.107.126094.

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