Mark Wefers Bettink

Chapter 1 14 References 1. Ince, C. & Mik, E. G. Microcirculatory and mitochondrial hypoxia in sepsis, shock, and resuscitation. Journal of applied physiology (Bethesda, Md. : 1985) 120 , 226–235 (2016). 2. Spronk, P. E., Zandstra, D. F. & Ince, C. Bench-to-bedside review: Sepsis is a disease of the microcirculation. Critical Care 8 , 1 (2004). 3. Ince, C. et al. Heterogeneity of the hypoxic state in rat heart is determined at capillary level. The American journal of physiology 264 , H294-301 (1993). 4. Ince, C. & Sinaasappel, M. Microcirculatory oxygenation and shunting in sepsis and shock. Critical Care Medicine 27 , 1369–1377 (1999). 5. Vanderkooi, J. M., Erecińska, M. & Silver, I. A. Oxygen in mammalian tissue: methods of measurement and affinities of various reactions. The American journal of physiology 260 , C1131- 50 (1991). 6. Schumacker, P. T., Chandel, N. & Agusti, A. G. Oxygen conformance of cellular respiration in hepatocytes. The American journal of physiology 265 , L395-402 (1993). 7. Arthur, P. G., Giles, J. J. & Wakeford, C. M. Protein synthesis during oxygen conformance and severe hypoxia in the mouse muscle cell line C2C12. Biochimica et biophysica acta 1475 , 83–89 (2000). 8. Fink, M. P. Bench-to-bedside review: Cytopathic hypoxia. Critical Care 6 , 491–499 (2002). 9. Fink, M. Cytopathic hypoxia in sepsis. Acta anaesthesiologica Scandinavica 41 , 87–95 (1997). 10. Genderen, M. E. van et al. Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock. Critical Care Medicine 42 , e96–e105 (2014). 11. Mik, E. G. et al. Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX. Nature methods 3 , 939–945 (2006). 12. Ubbink, R. et al. A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level. Journal of clinical monitoring and computing 1–8 (2016) doi:10.1007/s10877-016-9966-x. 13. Mik, E. G. et al. In Vivo Mitochondrial Oxygen Tension Measured by a Delayed Fluorescence Lifetime Technique. Biophysical journal 95 , 3977–3990 (2008). 14. Mik, E. G., Donkersloot, C., Raat, N. J. H. & Ince, C. Excitation pulse deconvolution in luminescence lifetime analysis for oxygen measurements in vivo. Photochemistry and photobiology 76 , 12–21 (2002). 15. Harms, F. A., Voorbeijtel, W. J., Bodmer, S. I. A., Raat, N. J. H. & Mik, E. G. Cutaneous respirometry by dynamic measurement of mitochondrial oxygen tension for monitoring mitochondrial function in vivo. Mitochondrion 13 , 507–514 (2013).