Mark Wefers Bettink

Chapter 7 142 References 1. Hatfield KM, Dantes RB, Baggs J, et al.: Assessing Variability in Hospital-Level Mortality Among U.S. Medicare Beneficiaries With Hospitalizations for Severe Sepsis and Septic Shock*. Critical Care Medicine 2018; 46:1753–1760 2. Rhodes A, Phillips G, Beale R, et al.: The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive care medicine 2015; 41:1620–1628 3. Brealey D, Karyampudi S, Jacques TS, et al.: Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. American journal of physiology Regulatory, integrative and comparative physiology 2004; 286:R491-7 4. Fink MP: Bench-to-bedside review: Cytopathic hypoxia. Critical Care 2002; 6:491–499 5. Galley HF: Oxidative stress and mitochondrial dysfunction in sepsis. Brit J Anaesth 2011; 107:57– 64 6. Garrabou G, Morén C, López S, et al.: The Effects of Sepsis on Mitochondria. The Journal of infectious diseases 2012; 205:392–400 7. Brealey D, Brand M, Hargreaves I, et al.: Association between mitochondrial dysfunction and severity and outcome of septic shock. [Internet]. Lancet (London, England) 2002; 360:219–223Available from: https://reader.elsevier.com/reader/sd/pii/S014067360209459X?t oken=9ACCC8DD892DB-14807BDBF5DD5969D35A1B6ED275A8E5130ACEADAFEE5C254E2266 E69E977D0F39D0D0811EFFC58EFB8 8. Nakahira K, Kyung S-Y, Rogers AJ, et al.: Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS medicine 2013; 10:e1001577-discussion e1001577 9. Yan HP, Li M, Lu XL, et al.: Use of plasma mitochondrial DNA levels for determining disease severity and prognosis in pediatric sepsis: a case control study. BMC pediatrics 2018; 18:267 10. Jeger V, Djafarzadeh S, Jakob SM, et al.: Mitochondrial function in sepsis. European journal of clinical investigation 2013; 43:532–542 11. Mik EG, Stap J, Sinaasappel M, et al.: Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX [Internet]. Nature methods 2006; 3:939–945Available from: message: %3CA1ABF921A3CB514B8CA6A7C11361748A8542C04E@EXCH-HE04.erasmus mc. nl%3E 12. Mik EG, Johannes T, Zuurbier CJ, et al.: In Vivo Mitochondrial Oxygen Tension Measured by a Delayed Fluorescence Lifetime Technique. Biophysical journal 2008; 95:3977–3990 13. Mik EG: Measuring Mitochondrial Oxygen Tension. Anesthesia Analgesia 2013; 117:834–846 14. Harms FA, Stolker RJ, Mik E: Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers. PloS one 2016; 11:e0159544 15. Harms FA, Bodmer SIA, Raat NJH, et al.: Non-invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique. Critical care (London, England) 2015; 19:343 16. Bettink MAW, Harms FA, Dollée N, et al.: Non-invasive versus ex vivo measurement of mitochondrial function in an endotoxemia model in rat: Toward monitoring of mitochondrial therapy. Mitochondrion 2020; 50:149–157