Mark Wefers Bettink

Monitoring of mitochondrial oxygen tension in the operating theatre 8 161 References 1 Springett, R. & Swartz, H. M. Measurements of oxygen in vivo: overview and perspectives on methods to measure oxygen within cells and tissues. Antioxid Redox Signal 9 , 1295-1301, doi:10.1089/ars.2007.1620 (2007). 2 Mik, E. G. et al. Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX. Nat Methods 3 , 939-945, doi:nmeth940 [pii] 10.1038/nmeth940 (2006). 3 Wefers Bettink, M. A. et al. Non-invasive versus ex vivo measurement of mitochondrial function in an endotoxemia model in rat: Toward monitoring of mitochondrial therapy. Mitochondrion 50 , 149-157, doi:S1567-7249(19)30098-4 [pii] 10.1016/j.mito.2019.11.003 (2020). 4 Harms, F. A. & Mik, E. G. In vivo assessment of mitochondrial oxygen consumption. Methods Mol Biol 1264 , 219-229, doi:10.1007/978-1-4939-2257-4_20 (2015). 5 Ubbink, R. et al. A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level. J Clin Monit Comput 31 , 1143-1150, doi:10.1007/s10877- 016-9966-x 10.1007/s10877-016-9966-x [pii] (2017). 6 Mik, E. G., Balestra, G. M. & Harms, F. A. Monitoring mitochondrial PO2: the next step. Curr Opin Crit Care 26 , 289-295, doi:10.1097/MCC.0000000000000719 (2020). 7 Harms, F. A., Stolker, R. J. & Mik, E. G. Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers. PLoS One 11 , e0159544, doi:10.1371/journal.pone.0159544 PONE-D-15-48673 [pii] (2016). 8 Ubbink, R., Wefers Bettink, M. A., van Weteringen, W. & Mik, E. G. Mitochondrial oxygen monitoring with COMET: verification of calibration in man and comparison with vascular occlusion tests in healthy volunteers. J Clin Monit Comput , doi:10.1007/s10877-020-00602-y 10.1007/s10877-020-00602-y [pii] (2020). 9 Mik, E. G. et al. In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique. Biophys J 95 , 3977-3990, doi:S0006-3495(08)78536-9 [pii] 10.1529/ biophysj.107.126094 (2008). 10 Bodmer, S. I. et al. Microvascular and mitochondrial PO(2) simultaneously measured by oxygen- dependent delayed luminescence. J Biophotonics 5 , 140-151, doi:10.1002/jbio.201100082 (2012). 11 Golub, A. S., Popel, A. S., Zheng, L. & Pittman, R. N. Analysis of phosphorescence in heterogeneous systems using distributions of quencher concentration. Biophys J 73 , 452-465, doi:S0006-3495(97)78084-6 [pii] 10.1016/S0006-3495(97)78084-6 (1997). 12 Faul, F., Erdfelder, E., Lang, A.-G. & Buchner, A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods 39 , 175- 191, doi:10.3758/BF03193146 (2007). 13 Mik, E. G. Special article: measuring mitochondrial oxygen tension: from basic principles to application in humans. Anesth Analg 117 , 834-846, doi:ANE.0b013e31828f29da [pii] 10.1213/ ANE.0b013e31828f29da (2013). 14 Wefers Bettink, M. A., Arbous, M. S., Raat, N. J. & Mik, E. G. Mind the mitochondria! J Emerg Crit Care Med 3 , 1-13, doi:10.21037/jeccm.2019.08.08 (2019). 15 Steinbrook, R. A. & Seigne, P. W. Total-body oxygen consumption after isoflurane anesthesia: effects of mild hypothermia and combined epidural-general anesthesia. J Clin Anesth 9 , 559-563, doi:S095281809700144X [pii] 10.1016/s0952-8180(97)00144-x (1997). 16 Johri, A. & Beal, M. F. Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 342 , 619-630, doi:jpet.112.192138 [pii]10.1124/jpet.112.192138 (2012).