Mark Wefers Bettink

A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level 3 59 18. Fukuda H, Casas A, Batlle A (2005) Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy. Int J Biochem Cell Biol 37:272–6. doi: 10.1016/j. biocel.2004.04.018 19. Mik EG, Donkersloot C, Raat NJH, Ince C (2002) Excitation pulse deconvolution in luminescence lifetime analysis for oxygen measurements in vivo. Photochem Photobiol 76:12–21. doi: 10.1562 /0031-8655(2002)076 <0012 20. Johannes T (2005) Dual-wavelength phosphorimetry for determination of cortical and subcortical microvascular oxygenation in rat kidney. J Appl Physiol 100:1301–1310. doi: 10.1152/ japplphysiol.01315.2005 21. Golub AS, Popel AS, Zheng L, Pittman RN (1997) Analysis of phosphorescence in heterogeneous systems using distributions of quencher concentration. Biophys J 73:452–65. doi: 10.1016/ S0006-3495(97)78084-6 22. Kennedy JC, Pottier RH (1992) Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. J Photochem Photobiol B 14:275–92. 23. Malik Z, Kostenich G, Roitman L, et al (1995) Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. J Photochem Photobiol B 28:213–8. 24. Goff BA, Bachor R, Kollias N, Hasan T (1992) Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs. J Photochem Photobiol B 15:239–51. 25. Sandby-Møller J, Poulsen T, Wulf HC (2003) Epidermal thickness at different body sites: relationship to age, gender, pigmentation, blood content, skin type and smoking habits. Acta Derm Venereol 83:410–3. doi: 10.1080/00015550310015419 26. Campbell I (2008) Body temperature and its regulation. Anaesth Intensive Care Med 9:259–263. doi: 10.1016/j.mpaic.2008.04.009 27. Römers LHL, Bakker C, Dollée N, et al (2016) Cutaneous Mitochondrial PO2, but Not Tissue Oxygen Saturation, Is an Early Indicator of the Physiologic Limit of Hemodilution in the Pig. Anesthesiology 125:124–32. doi: 10.1097/ALN.0000000000001156 28. O’Brien EO, Schmidt U (2016) Cellular Hypoxia in a Brand New Light. Anesthesiology 125:20–21. doi: 10.1097/ALN.0000000000001157 29. Harms F, Stolker RJ, Mik E (2016) Cutaneous respirometry as novel technique to monitor mitochondrial function: A feasibility study in healthy volunteers. PLoS One 11:163399. doi: 10.1371/journal.pone.0159544 30. Meglinsky IV, Matcher SJ (2001) Modelling the sampling volume for skin blood oxygenation measurements. Med Biol Eng Comput 39:44–50. doi: 10.1007/BF02345265 31. Vongsavan N, Matthews B (1993) Some aspects of the use of laser Doppler flow meters for recording tissue blood flow. Exp Physiol 78:1–14. 32. Guyotat J, Pallud J, Armoiry X, et al (2016) 5-Aminolevulinic Acid-Protoporphyrin IX Fluorescence- Guided Surgery of High-Grade Gliomas: A Systematic Review. Adv Tech Stand Neurosurg 61–90. doi: 10.1007/978-3-319-21359-0_3 33. Namikawa T, Yatabe T, Inoue K, et al (2015) Clinical applications of 5-aminolevulinic acid- mediated fluorescence for gastric cancer. World J Gastroenterol 21:8769–75. doi: 10.3748/wjg. v21.i29.8769