Mark Wefers Bettink

Chapter 4 70 A) n=10 included= n=9 baseline= n=9 KCN crème applied= n=9 not sufficient signal quality= n=10 new inclusions= n=9 KCN crème applied= n=9 oxygen consumption comparison occlusion test= n=1 excluded hemoglobinopathy n=1 no PpIX signal Session 1 Session 2 n=0 KCN mitoPO 2 data B) MitoPO 2 = 0 MitoPO 2 = arterial Dynamic measurement Arterial occlusion measurement Couveuse; PO 2 < 5 mmHg, temp 37 ℃ Arterial occlusion + pressure on sensor, data used from first session Couveuse; PO 2 < 5 mmHg of arterial PO 2 , temp 37 C Cyanide primed skin, data used from second session Check if mitochondrial respiration has returned. Pressure on COMET sensor, not in couveuse Data used from first session Arterial occlusion, not in couveuse, Data used from first session Vitals and arterial sample Figure 3 : A)Diagram of study subject flow, B) Diagram of methods timeline