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134 | Chapter 5 Statistical analysis Data were analyzed using GraphPad Prism version 6 (GraphPad Software, San Diego, CA). Differences between conditions were determined using one-way ANOVA or two-way ANOVA with multiple comparisons between column means, unpaired-t-test and log rank (Mantel-cox) test as deemed appropriate. A p-value of <0.05 was considered statistically significant. Acknowledgements The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7- PEOPLE-2012-ITN under REA grant agreement n° 317013 (NATURIMMUN consortium) This work was partly funded by the French program "Investissement d'Avenir" run by the 'Agence Nationale pour la Recherche'; grant ‘Infrastructure d'avenir en Biologie Santé - ANR- 11-INBS-0006'. We are grateful to M.A. Nicola (Imagopole, Institut Pasteur) for her support with the mouse imaging studies. The authors like to thank all the healthy volunteers and colorectal cancer patients that participated in this study.