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CONTENTS Chapter 1: General introduction and Scope of this Thesis Adapted in part from “The rise of allogeneic Natural Killer cells as a platform for cancer immunotherapy: Recent innovations and future developments” Frontiers in Immunology, 2017 Chapter 2: Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function Scientific Reports, 2017 Chapter 3: High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status Cancer Immunology and Immunotherapy, 2017 Chapter 4: Combination of NK cells and cetuximab to enhance anti-tumor responses in RAS mutant metastatic colorectal cancer PLOS ONE, 2016 Chapter 5: In vivo efficacy of umbilical cord blood stem cell-derived NK Cells in the treatment of metastatic colorectal cancer Frontiers in Immunology, 2017 Chapter 6: General discussion and Future Prospects Adapted in part from “The rise of allogeneic Natural Killer cells as a platform for cancer immunotherapy: Recent innovations and future developments” Frontiers in Immunology, 2017 Chapter 7: Summary Nederlandse samenvatting Curriculum vitae List of publications Acknowledgements 7 35 73 95 119 143 163 166 169 170 172